Symptoms
Symptoms of islet cell tumors are often caused by hormones produced by the tumor. Since non-functioning islet cell tumors do not secrete excess hormones, many non-functioning tumors are found incidentally, without symptoms, or on imaging tests for unrelated symptoms. Symptoms of functioning tumors depend on the specific hormone(s) overproduced. Minority of pancreatic neuroendocrine tumors can produce adrenocorticotropin hormone (ACTH) that is usually produced in the pituitary gland (ectopic ACTH production). Excessive ACTH production can stimulate the adrenal glands to produce too much cortisol (Cushing syndrome) leading to high blood pressure, high blood sugar, weight gain, stretch marks and swelling in legs.
