Diarrhea (loose, watery stools) is another potential side effect of radiation therapy. You may experience this side effect when receiving radiation therapy to the pelvic or abdominal region. Radiation therapy can damage the rapidly dividing cells in the digestive tract and lead to watery bowel movements. Talk to your doctor if you experience excessive or uncontrollable diarrhea. This side effect can be life-threatening if not properly managed. It can lead to more serious conditions like dehydration, malnutrition, pain, and inflammation. Your doctor can prescribe medications to prevent diarrhea and to help absorb all of the nutrients from your food.